Intradermal Test as an Index of Vitamin-C Nutrition of the Body —Observations at Vizagapatam *Paper read before the section of Physiology during the 28th Annual Session of the Indian Science Congress, Benares, 1941.
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چکیده
suffering from a deficiency of vitamin C. Portnoy and Wilkinson (1938) confirmed the results obtained by Rotter. They also stated that they found a good correlation between the level of blood ascorbic acid and the decolorization time of the intradermal test in 103 patients. Later, Wright and MacLenathen (1939) who also investigated dietary history and determined blood ascorbic acid levels, gave the contrary opinion that Rotter's test was not a reliable guide for the vitamin-C status of the bodyMeanwhile, Sujuki (1939) observed the decolorization time of Rotter's test to be inversely proportional to the ascorbic acid level of blood both in normal healthy human subjects and in pathological states. Beck and Krieger (1939) also considered the test as adequate for all practical purposes. In India, Banerjee and Gulia (1939) investigated how far the test could serve as a correct index of vitamin-C nutrition. In their experiments, the time of decolorization was longest in scorbutic guinea-pigs and was definitely diminished when ascorbic acid was added to the diet of the same animals and was prolonged again by withholding the supplement of ascorbic acid. In human subjects, they found that administration of massive doses of ascorbic acid resulted in reduction of the decolorization time. More recently, Banerjee and Guha (1940) reported again on experiments on guinea-pigs and human subjects, where an attempt was made to find out the minimum decolorization time. They
منابع مشابه
A Study of the Intradermal Test of Rotter for Vitamin C Status
was suggested by Rotter (1937). He observed that when 0.01 c.cm. of a N/400 solution of the dye 2 : 6-dichlorophenol indophenol was injected intradermally, the colour of the dye disappeared gradually. When methyl blue was similarly injected, its colour remained unchanged, which showed that the decolorization of dichlorophenol indophenol was not due to resorption but to reduction. Rotter (1938) ...
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